解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:T helper cells can differentiate into several subsets of T lymphocytes, including Th1, Th2, and regulatory T (Treg) cells. As a result of this ability to differentiate, the corresponding T cell receptor (TCR) spectra display considerable cellular plasticity and interchangeability. In contrast, T lymphocyte d...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2017.02.007
更新日期:2017-07-01 00:00:00
abstract::Sialoadhesin (Sn) is a surface receptor expressed on resident macrophages with the ability to bind with sialic acids. During inflammation, an upregulation of Sn is observed. Upon binding of monoclonal antibodies to Sn, the receptor becomes internalized and this has been observed in multiple species. The latter charact...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2016.11.013
更新日期:2017-06-01 00:00:00
abstract::Airway epithelial cells induce a tolerogenic microenvironment by modulating immune cells in the lung. We recently showed that the supernatant of airway epithelial cells induces two marker genes of alternative activation, Ym1 and Ms4a8a, in respiratory myeloid cells. This induction was partially mediated by glucocortic...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2017.02.003
更新日期:2017-05-01 00:00:00
abstract::Periodontitis is a chronic oral pathology caused by impaired immune response against oral bacteria resulting in tissue inflammation and damage. Among the members of innate immune response, the first line of defence against pathogens, inflammasomes are macro-molecular protein complexes that can be activated by differen...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2017.01.001
更新日期:2017-05-01 00:00:00
abstract::Tumor necrosis factor superfamily (TNFSF) represents a group of multifunctional inflammatory cytokines that have been shown to participate in a variety of pathological and immunological process. However, the functions of these proteins in oyster are still poorly understood. In the present study, an oyster TNF homolog ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2017.02.002
更新日期:2017-05-01 00:00:00
abstract::Canine visceral leishmaniasis (CVL) is known to affect the cellular immunity of infected dogs, through impairing lymphoproliferation and microbicidal mechanisms. This study examined heme oxygenase-1 (HO-1) and its metabolites, oxidative stress and IL-10 levels in CVL and investigated correlations between these paramet...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2016.12.006
更新日期:2017-05-01 00:00:00
abstract::The prevailing paradigm defines sarcoidosis as a disease of unknown etiology characterized by a systemic noncaseating epithelioid granulomatous response (SGR). This formulation fails to account for the elusiveness of the etiological agent, the nature of the Kveim response, the paradox of cutaneous delayed type hyperse...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/j.imbio.2016.12.005
更新日期:2017-04-01 00:00:00
abstract:INTRODUCTION:Fexofenadine (FXF) is a third-generation antihistamine drug and osthole is assumed as a natural antihistamine alternative. This paper compares results of histamine, FXF and osthole impact on HRH-1, COX-2, NF-κB-p50, CCR1 mRNA expression. We also measured mRNA expression of IL-1β and CCL5/RANTES in incubate...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2016.11.004
更新日期:2017-03-01 00:00:00
abstract::Macrophages orchestrate the initiation and resolution of inflammation by producing pro- and anti-inflammatory products. An imbalance in these mediators may originate from a deficient or excessive immune response. Therefore, macrophages are valid therapeutic targets to restore homeostasis under inflammatory conditions....
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2016.08.010
更新日期:2017-02-01 00:00:00
abstract::Psoriatic inflammation has been shown to be associated with cardiovascular dysfunction and systemic inflammation. Recently, psoriasis has also been linked to hepatic disorders, however underlying mechanism connecting the two are unknown. IL-17A being a central pro-inflammatory cytokine in the pathogenesis of psoriasis...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2016.10.013
更新日期:2017-02-01 00:00:00
abstract::Neutrophils, the most abundant leukocyte in human circulation are being more and more recognized as part of the immune reaction to cancer. In the last years, the understanding that neutrophils possess a dual role in cancer development has emerged. During tumor progression the number of neutrophils increase, and their ...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/j.imbio.2016.02.001
更新日期:2017-01-01 00:00:00
abstract::Several papers have demonstrated the importance of substances from natural sources which can exert powerful anti-inflammatory effects. In this respect, hydroxytyrosol, one of the major elements of the phenolic components of olive oil, has been extensively studied for its anti-inflammatory activities and safety profile...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2016.07.009
更新日期:2016-12-01 00:00:00
abstract::Both the complement system and collectins play important roles in our innate immune system. The collectins, which are characterized by their inclusion of a collagen-like region and a calcium-dependent carbohydrate recognition domain, are pattern recognition molecules and include the well characterized proteins mannan-...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/j.imbio.2016.05.012
更新日期:2016-10-01 00:00:00
abstract::T cells play a pivotal role in controlling the immune response and have been the focus of extensive research. We studied the process of in vitro generation of antigen-specific T effector cells (Teffs) to assess the dynamics of antigen presentation and determine the best conditions for cell therapy. We used a peptidic ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2016.04.001
更新日期:2016-08-01 00:00:00
abstract::Dogs infected with Leishmania infantum have a reduced number of T lymphocytes. PD-1 (Programmed cell death 1) a new member of the B7-CD28 family that is expressed by immune cells, and its binding to PD-L1 (CD274) or PD-L2 (CD273) induces the deactivation or apoptosis of T cells. This study aimed to evaluate the expres...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2016.03.007
更新日期:2016-08-01 00:00:00
abstract:INTRODUCTION:The interaction between the immune system and malignant diseases is a proven key target for cancer therapy. We describe an innovative 3D cell culture system comprising both immune and cancer cells to evaluate their interaction and immune cell infiltration to provide an innovative in vitro screening of immu...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2015.12.010
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Ficolins serve as soluble recognition molecules in the lectin pathway of complement. They are known to participate in the systemic host-response to infection but their role in local pulmonary defence is still incompletely understood. The purpose of this study was to clarify whether acute lung and systemic in...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2015.11.015
更新日期:2016-05-01 00:00:00
abstract::It is established that (1) subclinical Bordetella pertussis colonization of the nasopharynx persists in highly vaccinated populations, and (2) B. pertussis toxin is a potent adjuvant that, when co-administered with neural antigens, induces neuropathology in experimental autoimmune encephalomyelitis, the principle anim...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2015.12.008
更新日期:2016-04-01 00:00:00
abstract::Paracoccidioides brasiliensis is a dimorphic fungus from the Paracoccidioides genus, which is the causative agent of paracoccidioidomycosis, a chronic, subacute or acute mycosis, with visceral and cutaneous involvement. This disease that is acquired through inhalation primarily attacks the lungs but, can spread to oth...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2015.09.003
更新日期:2016-02-01 00:00:00
abstract::The expression level of Mac-1 on the surface of neutrophils is an important indicator of neutrophil activation. Under pathological conditions, Mac-1 is believed a key adhesion molecule that facilitates cancer progression and mediates the adhesion of tumour cells to the endothelium of blood vessels. Our previous findin...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2015.10.003
更新日期:2016-02-01 00:00:00
abstract::Surfactant proteins SP-A and SP-D are pattern recognition innate immune molecules that belong to the C-type lectin family. In lungs, they play an important role in the clearance of pathogens and control of inflammation. SP-A and SP-D are also expressed in the female reproductive tract where they play an important role...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2015.09.019
更新日期:2016-02-01 00:00:00
abstract::Dogs with lymphoma are established as good model for human non-Hodgkin lymphoma studies. Canine cell lines derived from lymphomas may be valuable tools for testing new therapeutic drugs. In this context, we established a canine T-cell line, PER-VAS, from a primary aggressive T-cell lymphoma with large granular morphol...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2015.08.007
更新日期:2016-01-01 00:00:00
abstract::Autoimmune lymphoproliferative syndrome (ALPS) is a primary immunodeficiency caused by impaired Fas/FasL-mediated apoptosis of lymphocytes and is characterized by chronic nonmalignant or benign lymphoproliferation, autoimmune manifestations and expansion of double negative (DN) T-cells (TCRαβ+CD4-CD8-). Most cases of ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2015.08.004
更新日期:2016-01-01 00:00:00
abstract::Tuberculosis due to Mycobacterium tuberculosis infection is a leading cause of death worldwide. Recognition of this pathogen is crucial for the activation of innate and adaptive immune responses. Nucleotide-binding oligomerization domain (Nod)1 and Nod2 are cytoplasmic receptors that can detect unique muropeptides of ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2015.07.020
更新日期:2016-01-01 00:00:00
abstract::Regulatory T cells that express CD39 (CD39+ Treg) exhibit specific immunomodulatory properties. Ectonucleotidase CD39 hydrolyses ATP and ADP. ATP is a ligand of the P2X7 receptor and induces the shedding of CD62L and apoptosis. However, the role of ATP in CD39+ Treg cells has not been defined. Furthermore, NAD can act...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2015.07.018
更新日期:2016-01-01 00:00:00
abstract::We hypothesized that anti-citrullinated protein antibodies (ACPAs) could affect the expression of miRNAs in monocytes and contribute to the inflammatory responses in rheumatoid arthritis (RA). The expression profiles of 270 human miRNAs, co-cultured with ACPAs or human immunoglobulin G (IgG), were analyzed using real-...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2015.07.007
更新日期:2015-12-01 00:00:00
abstract::Pemphigus Vulgaris (PV), a relatively common autoimmune blistering disease in India, primarily mediated by anti-Desmoglein 3 (anti-Dsg3) autoantibodies. T-helper 17 (Th17) and T-regulatory (Treg) cells play significant role in regulating immune homeostasis in autoimmune disorders. To understand immunopathogenesis of P...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2015.06.008
更新日期:2015-10-01 00:00:00
abstract::Visceral leishmaniasis (VL) caused by Leishmania donovani persists as a major public health issue in tropical and subtropical areas of the world. Current treatment of this disease relies on use of drugs. It is doubtful that chemotherapy can alone eradicate the disease, so there is a need for an effective vaccine. Kill...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2015.05.014
更新日期:2015-09-01 00:00:00
abstract::Aggregatibacter actinomycetemcomitans is a Gram-negative bacterium frequently isolated from lesions of patients with localized aggressive periodontitis. Lipopolysaccharide (LPS), a major cell wall component of Gram-negative bacteria, stimulates innate immune cells via Toll-like receptor 4 (TLR4) to initiate inflammato...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2015.05.008
更新日期:2015-09-01 00:00:00
abstract::IL-33 targeting ST2 receptor (T1/ST2), expressed on Th2 cell surface, regulates the production of cytokines like IL-17A and IL-31. We studied the role of IL-33/ST2 axis in IL-31 and IL-17A production in patients with allergic rhinitis (AR) and with concomitant allergic asthma and rhinitis (AAR). 20 healthy control sub...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2015.02.005
更新日期:2015-08-01 00:00:00
abstract::Gut microbiota and probiotic strains play an important role in oral tolerance by modulating regulatory and effector cell components of the immune system. We have previously described the ability of Lactobacilli to influence both the innate and adaptive immunity to wheat gluten, a food antigen, in mouse. In this study,...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2015.01.004
更新日期:2015-06-01 00:00:00
abstract::Previous studies have demonstrated that methamphetamine (METH) alter inflammatory and anti-inflammatory cytokine production in the periphery. However, the effect of METH on lipopolysaccharide (LPS)-induced immune responses and its underlying mechanism of action remains unclear. The dopamine D3 receptor (D3R) plays an ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2014.12.021
更新日期:2015-06-01 00:00:00
abstract::The inhibitory anti-CTLA-4 antibody, ipilimumab, dramatically improved survival in a subgroup of metastatic melanoma patients. The majority, however, suffered autoimmune-related adverse events (irAEs), sometimes pathognomonic of acute graft-versus-host-disease (GVHD). This implies that the CTLA-4 blockade is not tumor...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2014.11.019
更新日期:2015-05-01 00:00:00
abstract::The mechanisms of tolerance induction occurring in the course of allergen-specific immunotherapy have not been elucidated in full detail. Our study aimed to characterize high zone tolerance in mouse models of type I allergy and of allergic airway inflammation induced by subcutaneous sensitization of mice with high dos...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2014.10.022
更新日期:2015-04-01 00:00:00
abstract::Trypanosoma cruzi is a real challenge to the host's immune system, because it requires strong humoral and cellular immune response to remove circulating trypomastigote forms, and to prevent the replication of amastigote forms in tissues, involving many regulator and effector components. This protozoan is responsible f...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2014.10.003
更新日期:2015-03-01 00:00:00
abstract::The CD83 molecule (CD83) is a well-known surface marker present on mature dendritic cells (mDC). In this study, we show that CD83 is also expressed on a subset of T cells which mediate regulatory T cell (Treg)-like suppressor functions in vitro and in vivo. Treg-associated molecules including CD25, cytotoxic T lymphoc...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2014.08.005
更新日期:2015-02-01 00:00:00
abstract::Functional polymorphisms in RNA recognizing toll like receptors (TLR) 3, 7, 8 and toll-interleukin-1 receptor domain containing adapter protein adapter (TIRAP) coding genes were investigated in 120 dengue cases [87 dengue fever (DF) cases and 33 dengue hemorrhagic fever (DHF) cases] and 109 healthy controls (HC) to id...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2014.09.020
更新日期:2015-01-01 00:00:00
abstract::Pregnancy is known to induce a transient depression of maternal cell-mediated immunity, to prevent rejection of the fetus, while at the same time it keeps adequate maternal host defense mechanisms to fight infection. Presently, the aim of this paper was to investigate a possible endocrine and immunologic alteration ob...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2014.09.005
更新日期:2015-01-01 00:00:00
abstract::Hepatitis B virus (HBV) continues to be a serious worldwide health problem despite the use of protective HBV vaccines and therapeutic regimens against chronic HBV infection. Chronic HBV patients cannot induce sufficient immune responses against the virus. HBV and its antigens are believed to suppress immune responses ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2014.07.020
更新日期:2014-12-01 00:00:00
abstract::Vitamin D [25(OH)D3] deficiency has been associated with asthma as in many inflammatory and autoimmune pathologies; however, there is still a lack of data about the effects of administration of vitamin D in immune regulation in young asthmatic patients. In this study, we investigated its inhibitory effect on the immun...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2014.07.009
更新日期:2014-11-01 00:00:00